16 Calcium and vascular smooth muscle contraction

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Calcium and vascular smooth muscle contraction.

Radioactive calcium flux in rabbit aorta was studied to evaluate factors regulating the movement of calcium into and out of the cell. Calcium content was estimated both from (1) the amount of Ca present in the tissue and the specific activity of Ca in the bathing medium, and (2) determination of chemical calcium by atomic absorption spectrophotometry. Calcium efflux was followed by washing aort...

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Oxygen and vascular smooth muscle contraction.

DETAR, REED, AND DAVID F. BOHR. Oxygen and vascular smooth muscle contraction. Am. J. Physiol. 214(Z): 241-244. 1968.-Oxygen tension is an important determinant of the contractile tension developed by isolated helical strips of rabbit aorta. A decrease in PO:! below 100 mm Hg causes the contractile response to epinephrine (l-3 pg/liter) to diminish linearly to near zero levels at < 1 mm Hg. If ...

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Vascular Smooth Muscle Calcium Channels

Voltage-gated Ca 21 channels of the plasma membrane open in response to changes in cell membrane potential, providing an important pathway for regulated entry of extracellular Ca ions. Ca channels comprise a family of structurally related proteins displaying tissueand stage-specific expression. They are classified as either high voltage-activated (HVA) or low voltage-activated (LVA) and can be ...

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Vascular smooth muscle contraction in hypertension

Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to increased vascular contraction and arterial remo...

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Calcium in the regulation of aldosterone secretion and vascular smooth muscle contraction.

A model of angiotensin II action has been developed in which the flow of information from cell surface to cell interior proceeds by two temporally distinct branches: a calmodulin branch largely responsible for initiating the response; and a C-kinase branch for sustaining it. There are at least two initial events: a prompt and sustained increase in calcium influx rate, and prompt hydrolysis of p...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1986

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-198610000-00070